Sitemap - 2026 - NeuroLipid Notebook

The Castle Under Siege

Why This Study Does Not Prove Omega-3s Are Harmful: A Critical Analysis of Liao et al. (2026)

Estrogen, the Membrane, and the APOE4 Brain: A Gain Signal Applied to a Biased System

The Choroid Plexus as a Lipid Triage Center: A Critique of Andriambelo and Plourde (2026) and a Hypothesis for APOE4-Dependent DHA Diversion

The Three-Hit Model: Why APOE4 Alone Doesn’t Explain the Brain’s DHA Deficit

Start Here: An ApoE4 Centered Model for Understanding Brain Health

The DHA Didn’t Miss the Brain — It Wasn’t Incorporated

The Back Door: What If Fish Oil Is Shutting Down the Brain’s Own DHA Factory?

The Omega-3 Gap in WHIMS: A Critique No One Has Made

The Hormone Your Brain Might Be Missing: Why Your HRT Regimen May Not Be Doing What You Think for DHA

The Food-Only Challenge: Replicating MY APOE4 Neuroprotective Supplement Protocol From Diet Alone

The Defense Architecture: Why 2,765 mg/day DHA Requires Support

How APOE4 Neurons Burn Through Their Own Membranes

A Novel Critique of the WHIMs Dementia Findings

We've been using A Cardiac Biomarker for a Brain Problem?!

A Change in Plans

The Rap Video for "ApoE4 DHA Drain" Diagram is Up!

The Vortex Diagram, now available as a rap!

The Drain: DHA's Journey and Three Places It Gets Lost

The Neurolipid Notebook Diagram Series: A Visual Roadmap from Membrane to Collapse

Case Series: Nurse Jeannie's Cell Membranes

The Vortex: APOE4 Hyperexcitability and Membrane Lipid Biology

APOE4, NELL2, and the Hyperexcitable Brain: A New Mechanistic Window into Alzheimer’s Risk

To Test or Not to Test...Fasting Insulin, that is...

What Female APOE4 Carriers Need to Know About Their Brain Immune Function: In Depth

The Omega-6 Paradox

I Started Testing My Patients’ Genes. Then I Tested My Own.

I Ran 3 Fatty Acid Tests in 10 Months — Here’s the Pattern I Didn’t Expect

PEA + Luteolin in APOE4: Understanding What’s Actually Going On

Rethinking the HRT ‘Critical Window’: A Membrane-Inflammatory Model of Estrogen Response

Could This New Form of Lithium Transform Alzheimer’s Prevention?

Lithium, Bipolar Disorder, and an Alzheimer's Pathway Hiding in Brain Cell Membranes

Could NAC Support Brain Health in APOE4 Carriers?

IL-17F, Neutrophils, and the Female ApoE4 Brain: A New Target for Intervention

I Went Looking for Oral Inflammation—and Found a Systemic Signal I Didn’t Expect

Fluoxetine: A Biologically Plausible Risk Amplifier in APOE4 Carriers

The Ketogenic Paradox for APOE4 Carriers

What APOE4 Carriers Can Do Today to Support Gut-Mediated Inflammation Resolution

The Microbial Bypass: Why Your Gut May Hold the Key to SPM Production in APOE4

Why SPMs Are Low in ApoE4 Carriers—and Why It Matters

Why the AA:DHA Ratio Matters — and What Happened After 5 Weeks Without Fish (APOE4 Edition)

Progesterone, cPLA2, and APOE4: Why Midlife Drops Affect Brain Health

How hormones, lipids, and nutrition shape long-term brain and metabolic health

Menopause, APOE4, and cPLA₂: How Calcium and Progesterone Loss Amplify Brain Inflammation

APOE4 Is a Calcium Signaling Disorder(?!)

Could an Asthma Drug Help APOE4 Carriers Calm Neuroinflammation?

What Your Omega3 Index Can (and Can’t) Tell You About cPLA2 Activity in APOE4 Carriers

APOE4, Betaine, and Brain Lipid Health: Supporting DHA & Membrane Repair

Lithium Deficiency: A Hidden Early Factor in Alzheimer’s — What APOE4 Carriers Need to Know

Rethinking APOE4: cPLA2, Membrane Vulnerability, and Why Fat Loss Drives Brain Inflammation

Understanding Hormonal Balance and Brain Health in Perimenopause: New Mechanistic Insights

Estrogen, DHA, and APOE4: Interactions in Brain Lipid Aging

Melatonin as a Mitochondrial Guardian in Neurodegeneration

EPA, DHA, and APOE4

Should this fish be on your dish?

Let Them Eat Fish!

What a 5-Week Omega-3 Washout Taught Me About EPA, APOE4, and Lipid Fragility