NeuroLipid Notebook

NeuroLipid Notebook

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Start Here: An ApoE4 Centered Model for Understanding Brain Health
A NeuroLipid Notebook Guide for New Readers.
 • Nurse Jeannie Capone
Why This Study Does Not Prove Omega-3s Are Harmful: A Critical Analysis of Liao et al. (2026)
A new study says omega-3 supplements accelerate cognitive decline.
 • Nurse Jeannie Capone
Estrogen, the Membrane, and the APOE4 Brain: A Gain Signal Applied to a Biased System
Estrogen Is Gain: Why the Same Hormone Produces Opposite Outcomes
 • Nurse Jeannie Capone
The Choroid Plexus as a Lipid Triage Center: A Critique of Andriambelo and Plourde (2026) and a Hypothesis for APOE4-Dependent DHA Diversion
The technical draft
 • Nurse Jeannie Capone
The Three-Hit Model: Why APOE4 Alone Doesn’t Explain the Brain’s DHA Deficit
FADS genotype, APOE4 catabolism, and dietary linoleic acid may converge to create a progressive, age-dependent failure of brain DHA incorporation — and…
 • Nurse Jeannie Capone
The DHA Didn’t Miss the Brain — It Wasn’t Incorporated
DHA reaches the brain in APOE4—but doesn’t always show up in neurons. This article explores how omega-6 competition and membrane state may limit DHA…
 • Nurse Jeannie Capone
The Back Door: What If Fish Oil Is Shutting Down the Brain’s Own DHA Factory?
Two mouse studies.
 • Nurse Jeannie Capone
The Omega-3 Gap in WHIMS: A Critique No One Has Made
AA:DHA ratio, DPA isomers, and the missing analysis in the most influential menopause-dementia study ever published.
 • Nurse Jeannie Capone
The Hormone Your Brain Might Be Missing: Why Your HRT Regimen May Not Be Doing What You Think for DHA
I recently published a major critique of the WHIMS data — arguing that the AA:DHA ratio, Ada:DHA ratio, the DPA isomers, and FADS genotype were all…
 • Nurse Jeannie Capone
The Food-Only Challenge: Replicating MY APOE4 Neuroprotective Supplement Protocol From Diet Alone
One Day. Every Nutrient. No Supplements. No Shortcuts.
 • Nurse Jeannie Capone
The Defense Architecture: Why 2,765 mg/day DHA Requires Support
Buffering my High-Dose DHA Protocol with several layers of support. What I'm taking and my rationale.
 • Nurse Jeannie Capone
How APOE4 Neurons Burn Through Their Own Membranes
A self-reinforcing loop in APOE4 brains—calcium, cPLA2, DHA loss, AA/AdA backfill—silently arms neuronal membranes with ferroptotic substrates over…
 • Nurse Jeannie Capone
NeuroLipid Notebook
NeuroLipid Notebook
A precision brain-reserve protocol using MFSD2A, LPC DHA, and lipid-pathway optimization for APOE4 carriers, cognitive resilience. A resource for forward-thinking clinicians and researchers.
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'We zijn toch niet gek?'
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